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Increased cerebrospinal fluid glutamine levels in depressed patients

Levine, Joseph ; Panchalingam, Kanagasabai ; Rapoport, Avraham ; Gershon, Samuel ; McClure, Richard J ; Pettegrew, Jay W

Biological psychiatry (1969), 2000-04, Vol.47 (7), p.586-593 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Increased cerebrospinal fluid glutamine levels in depressed patients
Autor: Levine, Joseph ; Panchalingam, Kanagasabai ; Rapoport, Avraham ; Gershon, Samuel ; McClure, Richard J ; Pettegrew, Jay W
Assuntos: 1H MRS ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Bipolar Disorder - cerebrospinal fluid ; Bipolar Disorder - metabolism ; Case-Control Studies ; creatine ; Creatine - cerebrospinal fluid ; Depression ; Depressive Disorder - cerebrospinal fluid ; Depressive Disorder - metabolism ; Female ; Glutamatergic system (aspartate and other excitatory aminoacids) ; glutamine ; Glutamine - cerebrospinal fluid ; Glutamine - metabolism ; Humans ; Hydroxybutyrates - cerebrospinal fluid ; Magnesium - cerebrospinal fluid ; Magnetic Resonance Spectroscopy ; Major depression ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sex Factors ; β-hydroxybutyrate
É parte de: Biological psychiatry (1969), 2000-04, Vol.47 (7), p.586-593
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background: There is increasing evidence for an association between alterations of brain glutamatergic neurotransmission and the pathophysiology of affective disorders. Methods: We studied the association between cerebrospinal fluid (CSF) metabolites, including glutamine, in unipolar and bipolar depressed patients versus control subjects using a proton magnetic resonance spectroscopy technique. Cerebrospinal fluid samples were obtained from 18 hospitalized patients with acute unmedicated severe depression without medical problems and compared with those of 22 control subjects. Results: Compared with the control group, the depressed patient group had significantly higher CSF glutamine concentrations, which correlated positively with CSF magnesium levels. Conclusions: These findings suggest an abnormality of the brain glial–neuronal glutamine/glutamate cycle associated with N-methyl- d-aspartate receptor systems in patients with depression.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Increased cerebrospinal fluid glutamine levels in depressed patients

Levine, Joseph ; Panchalingam, Kanagasabai ; Rapoport, Avraham ; Gershon, Samuel ; McClure, Richard J ; Pettegrew, Jay W

New York, NY: Elsevier Inc

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