skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis

Song, Lijiang ; Laureti, Luisa ; Corre, Christophe ; Leblond, Pierre ; Aigle, Bertrand ; Challis, Gregory L

Journal of antibiotics, 2014-01, Vol.67 (1), p.71-76 [Periódico revisado por pares]

Japan: Nature Publishing Group

Texto completo disponível

Citações Citado por
  • Título:
    Cytochrome P450-mediated hydroxylation is required for polyketide macrolactonization in stambomycin biosynthesis
  • Autor: Song, Lijiang ; Laureti, Luisa ; Corre, Christophe ; Leblond, Pierre ; Aigle, Bertrand ; Challis, Gregory L
  • Assuntos: Antibiotics, Antineoplastic - biosynthesis ; Antibiotics, Antineoplastic - chemistry ; Cytochrome P-450 Enzyme System - metabolism ; Hydroxylation ; Life Sciences ; Macrolides - chemistry ; Polyketides - chemistry
  • É parte de: Journal of antibiotics, 2014-01, Vol.67 (1), p.71-76
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Many polyketide antibiotics contain macrolactones that arise from polyketide synthase chain release via thioesterase (TE) domain-catalyzed macrolactonization. The hydroxyl groups utilized in such macrolactonization reactions typically derive from reduction of β-ketothioester intermediates in polyketide chain assembly. The stambomycins are a group of novel macrolide antibiotics with promising anticancer activity that we recently discovered via rational activation of a silent polyketide biosynthetic gene cluster in Streptomyces ambofaciens. Here we report that the hydroxyl group utilized for formation of the macrolactone in the stambomycins is derived from cytochrome P450-catalyzed hydroxylation of the polyketide chain rather than keto reduction during chain assembly. This is a novel mechanism for macrolactone formation in polyketide antibiotic biosynthesis.
  • Editor: Japan: Nature Publishing Group
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.