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International Consensus for the Dosing of Corticosteroids in Childhood‐Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

Chalhoub, Nathalie E. ; Levy, Deborah M. ; Rouster‐Stevens, Kelly ; Aggarwal, Amita ; Qiu, Tingting ; Merritt, Angela ; Onel, Karen ; Khubchandani, Raju P. ; Ciurtin, Coziana ; Kasapcopur, Ozgur ; Jelusic, Marija ; Ozen, Seza ; Klein‐Gitelman, Marisa S. ; Lim, Sern Chin ; Silva, Clovis A. ; Torres‐Jimenez, Alfonso‐Ragnar ; Trachana, Maria ; Devarajan, Prasad ; Brunner, Hermine I. ; Abulaban, Khalid ; Aguiar, Cassyanne ; Ahn, Sun‐Young ; Akoghlanian, Shoghik ; Aljaberi, Najla ; Angeles‐Han, Sheila ; Balboni, Imelda ; Barbar‐Smiley, Fatima ; Beary, John ; Brakeman, Paul ; Bridges, John ; Burgos‐Vargas, Ruben ; Cabral, David A. ; Cameto, Juan ; Chédeville, Gaëlle ; Chhakchhuak, Christine ; Chiraseveenuprapund, Peter ; Cifuentes Alvarado, Mayra ; De Quattro, Kimberly ; Dizon, Brian ; Duong, Minh Dien ; Eberhard, Anne ; Ede, Kaleo ; Espada, Graciela ; Fritz, Deborah ; Gilbert, Mileka ; Gittar, Patsy ; Greenbaum, Larry ; Grom, Alexei ; Gulati, Gaurav ; Hersh, Aimee ; Hiskey, Megan ; Hoffmann, Sarah ; Hollander, Matthew ; Houk, Lawrence ; Houk, J. Brian ; Hsieh, Elena W.Y. ; Hsu, Joyce ; Jensen, Paul ; Jurado, Rosario ; Kallash, Mahmoud ; Kamphuis, Sylvia ; Khanna, Surabhi ; Kim, Susan ; Kimseng, Karen Joy ; Kunder, Rebecca ; Lai, Jamie ; Laskin, Benjamin ; Linda, Wagner‐Weiner ; Lo, Mindy ; Lovell, Daniel ; Luggen, Michael ; Mansuri, Asif ; Mason, Sherene ; Mohammed, Abdul ; Moncrieffe, Halima ; Moorthy, Lakshmi ; Mosquera, Angela ; Myones, Barry ; Nocton, James ; Olson, Judyann ; Orrock, Janet ; Paim‐Marques, Luciana ; Pain, Clare ; Park, Catherine ; Pereira, Maria ; Rheault, Michelle ; Ronis, Tova ; Sadun, Rebecca ; Siddiqi, Nabeela ; Smitherman, Emily ; Srinivasalu, Hemalatha ; Syed, Reema ; Ting, Tracy ; Toth, Mary ; Turnier, Jessica ; Vashisht, Priyanka ; von Scheven, Emily ; Ware, Avis ; Wu, Eveline ; Lawson, Erica

Arthritis & rheumatology (Hoboken, N.J.), 2022-02, Vol.74 (2), p.263-273 [Periódico revisado por pares]

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Título:
International Consensus for the Dosing of Corticosteroids in Childhood‐Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis
Autor: Chalhoub, Nathalie E. ; Levy, Deborah M. ; Rouster‐Stevens, Kelly ; Aggarwal, Amita ; Qiu, Tingting ; Merritt, Angela ; Onel, Karen ; Khubchandani, Raju P. ; Ciurtin, Coziana ; Kasapcopur, Ozgur ; Jelusic, Marija ; Ozen, Seza ; Klein‐Gitelman, Marisa S. ; Lim, Sern Chin ; Silva, Clovis A. ; Torres‐Jimenez, Alfonso‐Ragnar ; Trachana, Maria ; Devarajan, Prasad ; Brunner, Hermine I. ; Abulaban, Khalid ; Aguiar, Cassyanne ; Ahn, Sun‐Young ; Akoghlanian, Shoghik ; Aljaberi, Najla ; Angeles‐Han, Sheila ; Balboni, Imelda ; Barbar‐Smiley, Fatima ; Beary, John ; Brakeman, Paul ; Bridges, John ; Burgos‐Vargas, Ruben ; Cabral, David A. ; Cameto, Juan ; Chédeville, Gaëlle ; Chhakchhuak, Christine ; Chiraseveenuprapund, Peter ; Cifuentes Alvarado, Mayra ; De Quattro, Kimberly ; Dizon, Brian ; Duong, Minh Dien ; Eberhard, Anne ; Ede, Kaleo ; Espada, Graciela ; Fritz, Deborah ; Gilbert, Mileka ; Gittar, Patsy ; Greenbaum, Larry ; Grom, Alexei ; Gulati, Gaurav ; Hersh, Aimee ; Hiskey, Megan ; Hoffmann, Sarah ; Hollander, Matthew ; Houk, Lawrence ; Houk, J. Brian ; Hsieh, Elena W.Y. ; Hsu, Joyce ; Jensen, Paul ; Jurado, Rosario ; Kallash, Mahmoud ; Kamphuis, Sylvia ; Khanna, Surabhi ; Kim, Susan ; Kimseng, Karen Joy ; Kunder, Rebecca ; Lai, Jamie ; Laskin, Benjamin ; Linda, Wagner‐Weiner ; Lo, Mindy ; Lovell, Daniel ; Luggen, Michael ; Mansuri, Asif ; Mason, Sherene ; Mohammed, Abdul ; Moncrieffe, Halima ; Moorthy, Lakshmi ; Mosquera, Angela ; Myones, Barry ; Nocton, James ; Olson, Judyann ; Orrock, Janet ; Paim‐Marques, Luciana ; Pain, Clare ; Park, Catherine ; Pereira, Maria ; Rheault, Michelle ; Ronis, Tova ; Sadun, Rebecca ; Siddiqi, Nabeela ; Smitherman, Emily ; Srinivasalu, Hemalatha ; Syed, Reema ; Ting, Tracy ; Toth, Mary ; Turnier, Jessica ; Vashisht, Priyanka ; von Scheven, Emily ; Ware, Avis ; Wu, Eveline ; Lawson, Erica
Assuntos: Adjudication ; Adolescent ; Age of Onset ; Antidepressants ; Autoimmune diseases ; Biopsy ; Child ; Children ; Chronic conditions ; Clinical trials ; Corticoids ; Corticosteroids ; Dosage ; Female ; Glomerular filtration rate ; Glucocorticoids - administration & dosage ; Humans ; Intravenous administration ; Kidneys ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - drug therapy ; Lupus nephritis ; Lupus Nephritis - etiology ; Male ; Nephritis ; Parameter identification ; Patients ; Physicians ; Proteinuria ; Ratings ; Retrospective Studies ; Systemic lupus erythematosus
É parte de: Arthritis & rheumatology (Hoboken, N.J.), 2022-02, Vol.74 (2), p.263-273
Notas: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Supported by Pediatric Musculoskeletal & Rheumatology Innovation Core center (PORTICO) (National Institute of Arthritis and Musculoskeletal and Skin Diseases [NIAMS] award P30‐AR‐076316, NIAMS award R34‐AR‐071651, an Institutional Clinical and Translational Science Award, and the National Center for Advancing Translational Sciences, NIH grant 8UL1‐TR‐000077). REDCap is supported by the NIH (grant UL1‐TR‐000445). Dr. Chalhoub's work was supported by the National Center for Advancing Translational Sciences (grant 2UL1‐TR‐001425) and the Internal Medicine Scholars Training for Academic Research (IM STAR) program. Dr. Savani's work was supported by NIH training grant T32‐AR‐050958. Dr. Deng's work was supported by a Beijing Municipal Bureau of Foreign Affairs Training award. Dr. Ciurtin's work was supported by the Centre for Adolescent Rheumatology Versus Arthritis (grant 21593) and NIHR University College London Hospitals Biomedical Research Centre (grant BRC 525 III/CC). Dr. Silva's work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (grant CNPq 303422/2015‐7), Fundação de Amparo à Pesquisa do Estado de São Paulo (grant FAPESP 2015/03756‐4), and the Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” da USP (NAP‐CriAd). Dr. Devarajan's work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases, NIH (grant P50‐DK‐096418). The Childhood Arthritis and Rheumatology Research Alliance is supported in part by the Arthritis Foundation.
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Descrição: Objective To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood‐onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood‐onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood‐onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR‐recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion The SSR represents an international consensus on CS dosing for use in patients with childhood‐onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials.
Editor: Boston, USA: Wiley Periodicals, Inc
Idioma: Inglês

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International Consensus for the Dosing of Corticosteroids in Childhood‐Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis

Boston, USA: Wiley Periodicals, Inc

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