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Prevalence, incidence density, and genotype distribution of GB virus C infection in a cohort of recently HIV-1-infected subjects in Sao Paulo, Brazil

Giret, Maria Teresa M ; Miraglia, João Luiz ; Sucupira, Maria Cecília Araripe ; Nishiya, Anna ; Levi, José Eduardo ; Diaz, Ricardo S ; Sabino, Ester C ; Kallas, Esper G Belshaw, Robert

PloS one, 2011-04, Vol.6 (4), p.e18407-e18407 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Prevalence, incidence density, and genotype distribution of GB virus C infection in a cohort of recently HIV-1-infected subjects in Sao Paulo, Brazil
Autor: Giret, Maria Teresa M ; Miraglia, João Luiz ; Sucupira, Maria Cecília Araripe ; Nishiya, Anna ; Levi, José Eduardo ; Diaz, Ricardo S ; Sabino, Ester C ; Kallas, Esper G
Belshaw, Robert
Assuntos: Acquired immune deficiency syndrome ; Adult ; Age Distribution ; AIDS ; Analysis ; Antibodies ; Antiretroviral agents ; B cells ; Blood & organ donations ; Blood banks ; Brazil - epidemiology ; CD4 antigen ; CD4 Lymphocyte Count ; CD8 antigen ; CD8-Positive T-Lymphocytes - cytology ; Cell number ; Chronic illnesses ; Cladistic analysis ; Cloning ; Cohort Studies ; Correlation ; Density ; DNA polymerases ; Drugs ; Epidemiology ; GB virus ; Genetic aspects ; Genomes ; Genotype ; Genotype & phenotype ; Genotypes ; Geography ; Glycoprotein E2 ; Glycoproteins ; Health aspects ; Hemodialysis ; Hepatitis ; Hepatitis C - complications ; Hepatitis C - epidemiology ; Hepatitis C - genetics ; Hepatitis C - immunology ; Highly active antiretroviral therapy ; HIV ; HIV (Viruses) ; HIV Infections - complications ; HIV Infections - immunology ; HIV-1 - physiology ; Homosexuality ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Humans ; Immunology ; Incidence ; Infection ; Infections ; Infectious diseases ; Liver cancer ; Lymphocytes T ; Male ; Medical research ; Medicine ; Medicine, Experimental ; Patients ; Phylogeny ; Polymerase chain reaction ; Population ; Population studies ; Prevalence studies (Epidemiology) ; Ribonucleic acid ; RNA ; RNA-directed DNA polymerase ; Sequence Analysis, DNA ; Studies ; T cells ; Viral antibodies ; Viral Load ; Viruses ; Young Adult
É parte de: PloS one, 2011-04, Vol.6 (4), p.e18407-e18407
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Conceived and designed the experiments: MTMG EGK. Performed the experiments: MTMG MCAS AN. Analyzed the data: MTM JLM EGK. Contributed reagents/materials/analysis tools: MCAS JEL. Wrote the paper: MTMG JLM MCAS JEL RSD ECS EGK. Obtained funding: JEL RSD ECS EGK.
Descrição: The results of previous studies elsewhere have indicated that GB virus C (GBV-C) infection is frequent in patients infected with the human immunodeficiency virus type 1 (HIV-1) due to similar transmission routes of both viruses. The aim of this study was to determine the prevalence, incidence density and genotypic characteristics of GBV-C in this population. The study population included 233 patients from a cohort primarily comprised of homosexual men recently infected with HIV-1 in São Paulo, Brazil. The presence of GBV-C RNA was determined in plasma samples by reverse transcriptase-nested polymerase chain reaction and quantified by real-time PCR. GBV-C genotypes were determined by direct sequencing. HIV viral load, CD4+ T lymphocyte and CD8+ T lymphocyte count were also tested in all patients. The overall prevalence of GBV-C infection was 0.23 (95% CI: 0.18 to 0.29) in the study group. There was no significant difference between patients with and without GBV-C infection and Glycoprotein E2 antibody presence regarding age, sex, HIV-1 viral load, CD4+ and CD8+T cell counts and treatment with antiretroviral drugs. An inverse correlation was observed between GBV-C and HIV-1 loads at enrollment and after one year. Also, a positive but not significant correlation was observed between GBV-C load and CD4+ T lymphocyte. Phylogenetic analysis of the GBV-C isolates revealed the presence of genotype 1 and genotype 2, these sub classified into subtype 2a and 2b. GBV-C infection is common in recently HIV -1 infected patients in Sao Paulo, Brazil and the predominant genotype is 2b. This study provides the first report of the GBV-C prevalence at the time of diagnosis of HIV-1 and the incidence density of GBV-C infection in one year.
Editor: United States: Public Library of Science
Idioma: Inglês

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Prevalence, incidence density, and genotype distribution of GB virus C infection in a cohort of recently HIV-1-infected subjects in Sao Paulo, Brazil

Giret, Maria Teresa M ; Miraglia, João Luiz ; Sucupira, Maria Cecília Araripe ; Nishiya, Anna ; Levi, José Eduardo ; Diaz, Ricardo S ; Sabino, Ester C ; Kallas, Esper G Belshaw, Robert

United States: Public Library of Science

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