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Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty

Maquat, Lynne E

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2020-03, Vol.375 (1795), p.20190344-20190344 [Periódico revisado por pares]

England: The Royal Society

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  • Título:
    Short interspersed nuclear element (SINE)-mediated post-transcriptional effects on human and mouse gene expression: SINE-UP for active duty
  • Autor: Maquat, Lynne E
  • Assuntos: 3' Untranslated Regions - genetics ; Alu Elements - genetics ; Animals ; Gene Expression Regulation ; Humans ; Mice ; Retroelements ; Review ; RNA Stability ; Short Interspersed Nucleotide Elements - genetics ; Transcription, Genetic
  • É parte de: Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2020-03, Vol.375 (1795), p.20190344-20190344
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    One contribution of 15 to a discussion meeting issue ‘Crossroads between transposons and gene regulation’.
  • Descrição: Primate-specific Alu short interspersed nuclear elements (SINEs) and rodent-specific B and ID (B/ID) SINEs are non-autonomous and generally non-coding retrotransposons that have been copied and pasted into the respective genomes so as to constitute what is estimated to be a remarkable 13% and 8% of those genomes. In the context of messenger RNAs (mRNAs), those residing within 3'-untranslated regions (3'UTRs) can influence mRNA export from the nucleus to the cytoplasm, mRNA translation and/or mRNA decay via proteins with which they associate either individually or base-paired in or in with a partially complementary SINE. Each of these influences impinges on the primary function of mRNA, which is to serve as a template for protein synthesis. This review describes how human cells have used 3'UTR Alu elements to mediate post-transcriptional gene regulation and also describes examples of convergent evolution between human and mouse 3'UTR SINEs. This article is part of a discussion meeting issue 'Crossroads between transposons and gene regulation'.
  • Editor: England: The Royal Society
  • Idioma: Inglês
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