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GC content shapes mRNA storage and decay in human cells

Courel, Maïté ; Clément, Yves ; Bossevain, Clémentine ; Foretek, Dominika ; Vidal Cruchez, Olivia ; Yi, Zhou ; Bénard, Marianne ; Benassy, Marie-Noëlle ; Kress, Michel ; Vindry, Caroline ; Ernoult-Lange, Michèle ; Antoniewski, Christophe ; Morillon, Antonin ; Brest, Patrick ; Hubstenberger, Arnaud ; Roest Crollius, Hugues ; Standart, Nancy ; Weil, Dominique

eLife, 2019-12, Vol.8 [Periódico revisado por pares]

England: eLife Sciences Publications Ltd

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Título:
GC content shapes mRNA storage and decay in human cells
Autor: Courel, Maïté ; Clément, Yves ; Bossevain, Clémentine ; Foretek, Dominika ; Vidal Cruchez, Olivia ; Yi, Zhou ; Bénard, Marianne ; Benassy, Marie-Noëlle ; Kress, Michel ; Vindry, Caroline ; Ernoult-Lange, Michèle ; Antoniewski, Christophe ; Morillon, Antonin ; Brest, Patrick ; Hubstenberger, Arnaud ; Roest Crollius, Hugues ; Standart, Nancy ; Weil, Dominique
Assuntos: Base Composition - genetics ; Chromosomes and Gene Expression ; codon usage ; GC content ; Gene expression ; Gene Expression Regulation - genetics ; Humans ; Life Sciences ; Localization ; MicroRNAs - chemistry ; MicroRNAs - genetics ; mRNA decay ; mRNA stability ; mRNA storage ; mRNA turnover ; P-bodies ; Post-transcription ; post-transcriptional regulation ; Protein Biosynthesis - genetics ; RNA Stability - genetics ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; RNA, Messenger, Stored - chemistry ; RNA, Messenger, Stored - genetics ; Transcriptome - genetics ; Translation
É parte de: eLife, 2019-12, Vol.8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of broadly acting mRNA decay and repression factors, and with available CLIP and related data. This revealed the central role of GC content in mRNA fate, in terms of P-body localization, mRNA translation and mRNA stability: P-bodies contain mostly AU-rich mRNAs, which have a particular codon usage associated with a low protein yield; AU-rich and GC-rich transcripts tend to follow distinct decay pathways; and the targets of sequence-specific RBPs and miRNAs are also biased in terms of GC content. Altogether, these results suggest an integrated view of post-transcriptional control in human cells where most translation regulation is dedicated to inefficiently translated AU-rich mRNAs, whereas control at the level of 5' decay applies to optimally translated GC-rich mRNAs.
Editor: England: eLife Sciences Publications Ltd
Idioma: Inglês

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GC content shapes mRNA storage and decay in human cells

England: eLife Sciences Publications Ltd

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