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A global genetic interaction network maps a wiring diagram of cellular function

Costanzo, Michael ; VanderSluis, Benjamin ; Koch, Elizabeth N. ; Baryshnikova, Anastasia ; Pons, Carles ; Tan, Guihong ; Wang, Wen ; Usaj, Matej ; Hanchard, Julia ; Lee, Susan D. ; Pelechano, Vicent ; Styles, Erin B. ; Billmann, Maximilian ; van Leeuwen, Jolanda ; van Dyk, Nydia ; Lin, Zhen-Yuan ; Kuzmin, Elena ; Nelson, Justin ; Piotrowski, Jeff S. ; Srikumar, Tharan ; Bahr, Sondra ; Chen, Yiqun ; Deshpande, Raamesh ; Kurat, Christoph F. ; Li, Sheena C. ; Li, Zhijian ; Usaj, Mojca Mattiazzi ; Okada, Hiroki ; Pascoe, Natasha ; San Luis, Bryan-Joseph ; Sharifpoor, Sara ; Shuteriqi, Emira ; Simpkins, Scott W. ; Snider, Jamie ; Suresh, Harsha Garadi ; Tan, Yizhao ; Zhu, Hongwei ; Malod-Dognin, Noel ; Janjic, Vuk ; Przulj, Natasa ; Troyanskaya, Olga G. ; Stagljar, Igor ; Xia, Tian ; Ohya, Yoshikazu ; Gingras, Anne-Claude ; Raught, Brian ; Boutros, Michael ; Steinmetz, Lars M. ; Moore, Claire L. ; Rosebrock, Adam P. ; Caudy, Amy A. ; Myers, Chad L. ; Andrews, Brenda ; Boone, Charles

Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6306), p.1381-1381 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

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Título:
A global genetic interaction network maps a wiring diagram of cellular function
Autor: Costanzo, Michael ; VanderSluis, Benjamin ; Koch, Elizabeth N. ; Baryshnikova, Anastasia ; Pons, Carles ; Tan, Guihong ; Wang, Wen ; Usaj, Matej ; Hanchard, Julia ; Lee, Susan D. ; Pelechano, Vicent ; Styles, Erin B. ; Billmann, Maximilian ; van Leeuwen, Jolanda ; van Dyk, Nydia ; Lin, Zhen-Yuan ; Kuzmin, Elena ; Nelson, Justin ; Piotrowski, Jeff S. ; Srikumar, Tharan ; Bahr, Sondra ; Chen, Yiqun ; Deshpande, Raamesh ; Kurat, Christoph F. ; Li, Sheena C. ; Li, Zhijian ; Usaj, Mojca Mattiazzi ; Okada, Hiroki ; Pascoe, Natasha ; San Luis, Bryan-Joseph ; Sharifpoor, Sara ; Shuteriqi, Emira ; Simpkins, Scott W. ; Snider, Jamie ; Suresh, Harsha Garadi ; Tan, Yizhao ; Zhu, Hongwei ; Malod-Dognin, Noel ; Janjic, Vuk ; Przulj, Natasa ; Troyanskaya, Olga G. ; Stagljar, Igor ; Xia, Tian ; Ohya, Yoshikazu ; Gingras, Anne-Claude ; Raught, Brian ; Boutros, Michael ; Steinmetz, Lars M. ; Moore, Claire L. ; Rosebrock, Adam P. ; Caudy, Amy A. ; Myers, Chad L. ; Andrews, Brenda ; Boone, Charles
Assuntos: Cellular biology ; Diagrams ; Epistasis, Genetic ; Gene Regulatory Networks ; Genes ; Genes, Essential ; Genes, Fungal - physiology ; Genetic Pleiotropy - physiology ; Genetics ; Genotype & phenotype ; Mathematical models ; Medicin och hälsovetenskap ; Modules ; Networks ; Pathways ; RESEARCH ARTICLE SUMMARY ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae Proteins - genetics ; Wiring
É parte de: Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6306), p.1381-1381
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

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A global genetic interaction network maps a wiring diagram of cellular function

United States: American Association for the Advancement of Science

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