Idioma:

Relationships between cancer and aging: a multilevel approach

Anisimov, Vladimir N. ; Sikora, Ewa ; Pawelec, Graham

Biogerontology (Dordrecht), 2009-08, Vol.10 (4), p.323-338 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

Texto completo disponível

Citações Citado por

Enviar para

Título:
Relationships between cancer and aging: a multilevel approach
Autor: Anisimov, Vladimir N. ; Sikora, Ewa ; Pawelec, Graham
Assuntos: Age Distribution ; Age Factors ; Aging - genetics ; Aging - metabolism ; Animals ; Anticarcinogenic Agents - pharmacology ; Biguanides - pharmacology ; Biomedical and Life Sciences ; Carcinogens - toxicity ; Cell Biology ; Cell Proliferation - drug effects ; Cell Transformation, Neoplastic - chemically induced ; Cell Transformation, Neoplastic - drug effects ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Cellular Senescence - drug effects ; Developmental Biology ; Gene Expression Regulation, Neoplastic - drug effects ; Geriatrics/Gerontology ; Humans ; Incidence ; Life Sciences ; Neoplasms - epidemiology ; Neoplasms - etiology ; Neoplasms - genetics ; Neoplasms - pathology ; Neoplasms - prevention & control ; Review Article ; Risk Factors ; Signal Transduction - drug effects
É parte de: Biogerontology (Dordrecht), 2009-08, Vol.10 (4), p.323-338
Descrição: The incidence of cancer increases with age in humans and in laboratory animals alike. There are different patterns of age-related distribution of tumors in different organs and tissues. Aging may increase or decrease the susceptibility of various tissues to initiation of carcinogenesis and usually facilitates promotion and progression of carcinogenesis. Aging may predispose to cancer in two ways: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis, in particular, alterations in immune and endocrine systems. Increased susceptibility to the effects of tumor promoters is found both in aged animals and aged humans, as predicted by the multistage model of carcinogenesis. Aging is associated with a number of events at the molecular, cellular and physiological levels that influence carcinogenesis and subsequent cancer growth. An improved understanding of age-associated variables impacting on the tumor microenvironment, as well as the cancer cells themselves, will result in improved treatment modalities in geriatric oncology.
Editor: Dordrecht: Springer Netherlands
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Relationships between cancer and aging: a multilevel approach

Anisimov, Vladimir N. ; Sikora, Ewa ; Pawelec, Graham

Dordrecht: Springer Netherlands

Buscando em bases de dados remotas. Favor aguardar.