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Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation

Richards, JoAnne S. ; Ascoli, Mario

Trends in endocrinology and metabolism, 2018-05, Vol.29 (5), p.313-325 [Periódico revisado por pares]

United States: Elsevier Ltd

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Título:
Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation
Autor: Richards, JoAnne S. ; Ascoli, Mario
Assuntos: Animals ; Autocrine Communication - genetics ; Autocrine Communication - physiology ; cyclic nucleotides ; epidermal growth factor receptor ; ErbB Receptors - genetics ; ErbB Receptors - metabolism ; extracellular regulated kinase 1 and 2 ; Female ; Humans ; luteinizing hormone receptor ; Mitogen-Activated Protein Kinase 1 - genetics ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - genetics ; Mitogen-Activated Protein Kinase 3 - metabolism ; natriuretic peptide receptor ; Ovulation - genetics ; Ovulation - physiology ; Paracrine Communication - genetics ; Paracrine Communication - physiology ; Receptors, LH - genetics ; Receptors, LH - metabolism
É parte de: Trends in endocrinology and metabolism, 2018-05, Vol.29 (5), p.313-325
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: The central role of luteinizing hormone (LH) and its receptor (LHCGR) in triggering ovulation has been recognized for decades. Because the LHCGR is present in the mural (outermost) granulosa cell layer of preovulatory follicles (POFs), the LH-initiated signal has to be transmitted to another somatic cell type (cumulus granulosa cells) and the oocyte to release a fertilizable oocyte. Recent studies have shown that activation of the LHCGR initiates vectorial transfer of information among the two somatic cell types and the oocyte and the molecules and signaling pathways involved are now better understood. This review summarizes the newer developments on the complex signaling pathways that regulate ovulation. Ovulation is triggered when the ovulatory surge of LH activates the LHCGR in the mural granulosa cells of the ovarian follicle. This initial signal is propagated to the cumulus cells and the oocyte through paracrine and autocrine signaling pathways that result in the release of a fertilizable oocyte. The ovarian EGFR network and the ERK1/2 cascade, two pathways that are traditionally associated with cell proliferation, are activated by the LHCGR and are involved in (EGFR network) or essential to (ERK1/2) the ovulatory response. The signaling pathways that participate in ovulation provide an example of how the activation of a single receptor (LHCGR) in a single cell type results in the vectorial transfer of information among other cell types that do not express the receptor.
Editor: United States: Elsevier Ltd
Idioma: Inglês

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Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation

Richards, JoAnne S. ; Ascoli, Mario

United States: Elsevier Ltd

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