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Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes

McLean, Donald R. ; Clink, Hugh M. ; Ernst, Peter ; Coates, Robert ; Zuheir Al Kawi, M. ; Bohlega, Saeed ; Omer, Salah

Cancer, 1994-06, Vol.73 (12), p.3037-3040 [Periódico revisado por pares]

New York: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes
Autor: McLean, Donald R. ; Clink, Hugh M. ; Ernst, Peter ; Coates, Robert ; Zuheir Al Kawi, M. ; Bohlega, Saeed ; Omer, Salah
Assuntos: Adolescent ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Contrast Media ; Cytarabine - administration & dosage ; Cytarabine - adverse effects ; cytosine arabinoside ; Drug Combinations ; Drug toxicity and drugs side effects treatment ; Female ; Gadolinium DTPA ; Humans ; Injections, Spinal - adverse effects ; intrathecal chemotherapy ; Magnetic Resonance Imaging ; Medical sciences ; Meglumine ; methotrexate ; Methotrexate - administration & dosage ; Methotrexate - adverse effects ; Organometallic Compounds ; paraplegia ; Paraplegia - chemically induced ; Paraplegia - diagnosis ; Pentetic Acid - analogs & derivatives ; Pharmacology. Drug treatments ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; spinal cord ; Spinal Cord Diseases - chemically induced ; Spinal Cord Diseases - diagnosis ; Toxicity: nervous system and muscle
É parte de: Cancer, 1994-06, Vol.73 (12), p.3037-3040
Descrição: Background. Paraplegia caused by intrathecal chemotherapy has no known pathognomonic features and is a diagnosis of exclusion. Methods. The authors reported the clinical and neuroimaging findings in one patient with this syndrome. Results. The patient had severe paraplegia with urinary retention and impaired pain and touch sensation below T‐10 with sparing of proprioception and vibration sense. Magnetic resonance imaging (MRI) scan showed diminished intensity throughout the central cervical spinal cord. Post‐gadopentetate dimeglumine enhancement was scattered throughout the cervical spinal cord and in two areas of the dorsal spinal cord. Axial views of the cervical spinal cord showed that this enhancement was limited to the lateral columns. Conclusions. The MRI in myelopathy due to intrathecal chemotherapy may show a unique pattern of post‐gadopentetate dimeglumine enhancement limited to the lateral columns of the spinal cord. However, two recently encountered patients with the same syndrome did not show similar changes. Cancer 1994; 73:3037–40.
Editor: New York: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Myelopathy after intrathecal chemotherapy. A case report with unique magnetic resonance imaging changes

McLean, Donald R. ; Clink, Hugh M. ; Ernst, Peter ; Coates, Robert ; Zuheir Al Kawi, M. ; Bohlega, Saeed ; Omer, Salah

New York: Wiley Subscription Services, Inc., A Wiley Company

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