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Esophageal biomechanics assessed by impedance planimetry

Rabbione, Guillermo Jose Ortega ; Frances, Sergio Casabona ; Garcia, Ancor Sanz ; Lucendo, Alfredo J ; Santander, Cecilio ; Fernandez, Maria Teresa Perez ; Majano, Pedro ; de Leon, Antonio Ruiz

Revista española de enfermedades digestivas, 2023-12, Vol.115 (12), p.693 [Periódico revisado por pares]

Sociedad Espanola de Patologia Digestivas

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  • Título:
    Esophageal biomechanics assessed by impedance planimetry
  • Autor: Rabbione, Guillermo Jose Ortega ; Frances, Sergio Casabona ; Garcia, Ancor Sanz ; Lucendo, Alfredo J ; Santander, Cecilio ; Fernandez, Maria Teresa Perez ; Majano, Pedro ; de Leon, Antonio Ruiz
  • Assuntos: Biomechanics ; Care and treatment ; Comparative analysis ; Corticosteroids ; Deglutition disorders ; Esophagitis
  • É parte de: Revista española de enfermedades digestivas, 2023-12, Vol.115 (12), p.693
  • Descrição: Eosinophilic esophagitis is an inflammatory disease that affects the esophageal wall and prevents the patient from eating normally, and is reversible with appropriate treatment. In this study we analyzed and compared different properties of the esophageal wall using a device called EndoFLIP[TM] both in healthy people and in patients with eosinophilic esophagitis before and after a 6-week treatment with a swallowed topical corticosteroid. Ten healthy volunteers and 9 patients with eosinophilic esophagitis were included. We observed that esophageal contractions are the same in healthy subjects and in patients with eosinophilic esophagitis, while the ability of the esophagus to dilate and its diameter are decreased in patients, even after treatment, which may be due to the fact that 6 weeks is a short time. to see changes in this aspect. On the other hand, this is the first study in our environment that provides normal values for these esophageal measurements. Background: active eosinophilic esophagitis is associated with esophageal caliber, distensibility and motility changes that may be reversed with treatment. Objectives: to study esophageal diameter, distensibility and contractility in healthy subjects compared to patients with eosinophilic esophagitis, both before and after treatment. Methods: a quasi-experimental study, EndoFLIP[TM], was used to analyze the esophageal body and esophago-gastric junction (EGJ) in all three groups, and a program was designed to obtain esophageal diameter, distensibility and contractility values. Results: ten healthy volunteers (24-61 years, six men) and nine patients with eosinophilic esophagitis (21-52 years, seven men) were included. The esophagogastric junction distensibility index was 5.07 [mm.sup.2]/Hg in the control subjects, 2.40 [mm.sup.2]/Hg in the subjects with eosinophilic esophagitis before treatment and 2.46 [mm.sup.2]/Hg after treatment. The distensibility plateau was 20.02 mm, 15.43 mm and 17.41 mm, respectively, and the diameter was 21.90 mm, 17.73 mm and 18.30 mm, showing significant differences (p < 0.05), except between control subjects and patients after treatment (p = 0.079). Repetitive antegrade contractions developed in 90% of control subjects, 66.7% of eosinophilic esophagitis patients before treatment and 88.9% of the latter after treatment (p > 0.05). Conclusions: esophago-gastric junction distensibility index, distensibility plateau and diameter values were higher in controls than in patients, although six weeks of treatment seems a short period to observe significant changes in esophageal biomechanics. Repetitive antegrade contractions are the predominant pattern in healthy subjects and eosinophilic esophagitis. We provide normality values for esophageal biomechanics, measured by impedance planimetry in our setting. Keywords: Esophagus. Esophagogastric junction. Dysphagia. Eosinophilic esophagitis. Motor activity. Distensibility. Diameter.
  • Editor: Sociedad Espanola de Patologia Digestivas
  • Idioma: Espanhol
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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