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Bioactive Constituents of the Roots of Cynanchum atratum

DAY, Shiow-Hwa ; WANG, Jih-Pyang ; WON, Shen-Jeu ; LIN, Chun-Nan

Journal of natural products (Washington, D.C.), 2001-05, Vol.64 (5), p.608-611 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
Bioactive Constituents of the Roots of Cynanchum atratum
Autor: DAY, Shiow-Hwa ; WANG, Jih-Pyang ; WON, Shen-Jeu ; LIN, Chun-Nan
Assuntos: Animals ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; China ; General pharmacology ; Macrophages - drug effects ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Medical sciences ; Mice ; Microglia - drug effects ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Roots - chemistry ; Plants, Medicinal - chemistry ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Infrared
É parte de: Journal of natural products (Washington, D.C.), 2001-05, Vol.64 (5), p.608-611
Notas: ark:/67375/TPS-SDMT0ZFT-K
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Descrição: A novel biphenylneolignan, 2,6,2',6'-tetramethoxy-4,4'-bis(2,3-epoxy-1-hydroxypropyl)biphenyl (1), and two new glycosides named atratoglaucosides A (2) and B (3), were isolated from the roots of Cynanchum atratum, and their structures were determined on the basis of chemical and spectroscopic evidence. The aglycons of 2 and 3 were identified as glaucogenin C and 7-desoxyneocynapanogenin A, a new disecopregnane. A known compound, glaucogenin C 3-O-beta-D-cymaropyranosyl-(1-->4)-alpha-L-diginopyranosyl-(1-->4)-beta-D-thevetopyranoside (4), isolated from the same source, showed a significant cytotoxic effect against 212 cells. This substance also gave a significant inhibitory effect on TNF-alpha (tumor necrosis factor-alpha) formation from the RAW 264.7 mouse macrophage-like cell line stimulated with LPS (lipopolysaccharide) and on the N9 microglial cell line stimulated with LPS/IFN-gamma (interferon-gamma).
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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Bioactive Constituents of the Roots of Cynanchum atratum

DAY, Shiow-Hwa ; WANG, Jih-Pyang ; WON, Shen-Jeu ; LIN, Chun-Nan

Washington, DC: American Chemical Society

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