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Dendritic cells loading autologous tumor lysate promote tumor angiogenesis

Yang, Yi ; Lu, Jing ; Liu, Hangfan ; Jin, Guoguo ; Bai, Ruihua ; Li, Xiang ; Wang, Dongyu ; Zhao, Jimin ; Huang, Youtian ; Liu, Kangdong ; Xing, Ying ; Dong, Ziming

Tumor biology, 2016-12, Vol.37 (12), p.15687-15695 [Periódico revisado por pares]

Dordrecht: Springer Netherlands

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  • Título:
    Dendritic cells loading autologous tumor lysate promote tumor angiogenesis
  • Autor: Yang, Yi ; Lu, Jing ; Liu, Hangfan ; Jin, Guoguo ; Bai, Ruihua ; Li, Xiang ; Wang, Dongyu ; Zhao, Jimin ; Huang, Youtian ; Liu, Kangdong ; Xing, Ying ; Dong, Ziming
  • Assuntos: Angiogenesis ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Dendritic cells ; Original Article ; Rodents ; Tumors ; Vaccines
  • É parte de: Tumor biology, 2016-12, Vol.37 (12), p.15687-15695
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Dendritic cells (DC) have been exploited for vaccination against cancer for years. DC loading autologous tumor lysate (ATL-DC) have been assessed in ongoing clinical trials, but frequently do not meet expectation. In this study, we found that mice immunized with ATL-DC induced less protective anti-tumor effect than immunized with DC alone. The percentage of CD8 + T cells and the lysis efficiency of CTLs to auto tumor cells in ATL-DC vaccination group was less than that of DC group. Moreover, vaccination of mice with ATL-DC also promoted tumor angiogenesis by analyzing the CD31 positive microvessel density and hemoglobin content of tumor specimens. Human umbilical vein endothelial cells (HUVEC) have been proved effective in the anti-angiogenesis immunity against cancer. However, in the following research we found that the anti-tumor effect was attenuated while immunized mice with HUVEC combined with ATL-DC (HUVEC + ATL-DC). Furthermore, immunized mice with HUVEC + ATL-DC profoundly increased the tumor angiogenesis by analyzing the microvessel density and hemoglobin content of tumor specimens. These data suggest that vaccination using ATL-DC antagonized HUVEC induced anti-angiogenesis effect. Our research for the first time indicated that ATL-DC have the potential to promote the process of tumor angiogenesis in vivo . As vaccines based on DC loading autologous tumor lysate have been used in clinical, this find warned that the safety of this kind of vaccine should be taken into consideration seriously.
  • Editor: Dordrecht: Springer Netherlands
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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