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Effects of cations and temperature on the binding of ( super(3)H)spiperone to sheep caudate nucleus

Oliveira, C R ; Wajda, I ; Lajtha, A ; Carvalho, AP

Biochemical pharmacology, 1983-01, Vol.32 (3), p.417-422 [Periódico revisado por pares]

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  • Título:
    Effects of cations and temperature on the binding of ( super(3)H)spiperone to sheep caudate nucleus
  • Autor: Oliveira, C R ; Wajda, I ; Lajtha, A ; Carvalho, AP
  • Assuntos: caudate nucleus ; dopamine ; sheep ; spiperone
  • É parte de: Biochemical pharmacology, 1983-01, Vol.32 (3), p.417-422
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    content type line 23
    ObjectType-Feature-1
  • Descrição: The specific ( super(3)H)spiperone binding by sheep caudate nucleus homogenate is increased by divalent cations. The effect of Ca super(2+) or Mn super(2+) (5 mM) is temperature-dependent, and it is optimal at about 37 degree , but is relatively low below 15 degree and above 50 degree . In the absence of added Ca super(2-) or Mn super(2+), the maximal specific ( super(3)H)spiperone binding is observed at about 25 degree , and the cations shift the optimum to about 37 degree . Under the experimental conditions used, the K sub(D) is about 0.6 nM and is not influenced by Ca super(2-) or Mn super(2-), or by temperature (25 and 37 degree ). In addition to Ca super(2+) and Mn super(2+), Mg super(2+) and Zn super(2-) also increase the specific ( super(3)H)spiperone binding, but to a smaller extent. At the concentrations of Ca super(2-), Mn super(2+), Mg super(2-) and Zn super(2-) which produce a maximal increase in the ( super(3)H)spiperone binding, the membranes are nearly saturated with the cations which bind about 100 nmoles of Ca super(2+) or Mg super(2+)/mg of protein, 170 nmoles Zn super(2-)/mg of protein and at least 300 nmoles Mn super(2+)/mg of protein.
  • Idioma: Inglês
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