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Transferability of tag SNPs in genetic association studies in multiple populations

Altshuler, David ; de Bakker, Paul I W ; Burtt, Noël P ; Graham, Robert R ; Guiducci, Candace ; Yelensky, Roman ; Drake, Jared A ; Bersaglieri, Todd ; Penney, Kathryn L ; Butler, Johannah ; Young, Stanton ; Onofrio, Robert C ; Lyon, Helen N ; Stram, Daniel O ; Haiman, Christopher A ; Freedman, Matthew L ; Zhu, Xiaofeng ; Cooper, Richard ; Groop, Leif ; Kolonel, Laurence N ; Henderson, Brian E ; Daly, Mark J ; Hirschhorn, Joel N

Nature genetics, 2006-11, Vol.38 (11), p.1298-1303 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Transferability of tag SNPs in genetic association studies in multiple populations
Autor: Altshuler, David ; de Bakker, Paul I W ; Burtt, Noël P ; Graham, Robert R ; Guiducci, Candace ; Yelensky, Roman ; Drake, Jared A ; Bersaglieri, Todd ; Penney, Kathryn L ; Butler, Johannah ; Young, Stanton ; Onofrio, Robert C ; Lyon, Helen N ; Stram, Daniel O ; Haiman, Christopher A ; Freedman, Matthew L ; Zhu, Xiaofeng ; Cooper, Richard ; Groop, Leif ; Kolonel, Laurence N ; Henderson, Brian E ; Daly, Mark J ; Hirschhorn, Joel N
Assuntos: Biological and medical sciences ; Breast Neoplasms - ethnology ; Breast Neoplasms - genetics ; Case-Control Studies ; Chromosome Mapping - methods ; Clinical Medicine ; Cohort Studies ; Computer Simulation ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Variation ; Genetics of eukaryotes. Biological and molecular evolution ; Genetics, Population - methods ; Genome, Human ; Genomics ; Genotype & phenotype ; Human genome ; Human Genome Project ; Humans ; Identification and classification ; Klinisk medicin ; Linkage (Genetics) ; Linkage Disequilibrium ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Physiological aspects ; Polymorphism, Single Nucleotide ; Population genetics ; Prostatic Neoplasms - ethnology ; Prostatic Neoplasms - genetics ; Sequence Tagged Sites ; Single nucleotide polymorphisms
É parte de: Nature genetics, 2006-11, Vol.38 (11), p.1298-1303
Notas: ObjectType-Article-1
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Descrição: A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four HapMap population samples and eleven other population samples. We picked tag SNPs using genotype data we collected in the HapMap samples and then evaluated the effective coverage of these tags in comparison to the entire set of common variants observed in the other samples. We simulated case-control association studies in the non-HapMap samples under a disease model of modest risk, and we observed little loss in power. These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world.
Editor: London: Nature Publishing Group
Idioma: Inglês

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Transferability of tag SNPs in genetic association studies in multiple populations

London: Nature Publishing Group

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