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Role of the Formamide/Zirconia System in the Synthesis of Nucleobases and Biogenic Carboxylic Acid Derivatives

Saladino, Raffaele ; Neri, Veronica ; Crestini, Claudia ; Costanzo, Giovanna ; Graciotti, Michele ; Di Mauro, Ernesto

Journal of molecular evolution, 2010-08, Vol.71 (2), p.100-110 [Periódico revisado por pares]

New York: New York : Springer-Verlag

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Título:
Role of the Formamide/Zirconia System in the Synthesis of Nucleobases and Biogenic Carboxylic Acid Derivatives
Autor: Saladino, Raffaele ; Neri, Veronica ; Crestini, Claudia ; Costanzo, Giovanna ; Graciotti, Michele ; Di Mauro, Ernesto
Assuntos: Amides - chemical synthesis ; Amides - chemistry ; Animal Genetics and Genomics ; Biochemistry ; Biomedical and Life Sciences ; carboxylic acids ; Carboxylic Acids - chemical synthesis ; Carboxylic Acids - chemistry ; Catalysts ; Cell Biology ; Drug Stability ; Evolutionary Biology ; Formamide ; Formamides - pharmacology ; Life Sciences ; Microbiology ; Mineralogy ; Models, Biological ; Molecular biology ; Molecular Weight ; Nucleic Acids - chemical synthesis ; Nucleic acids stability ; Organic Chemicals - chemical synthesis ; Organic Chemicals - chemistry ; Plant Genetics and Genomics ; Plant Sciences ; purines ; Purines - chemical synthesis ; Purines - chemistry ; pyrimidines ; Pyrimidines - chemical synthesis ; Pyrimidines - chemistry ; RNA Stability - drug effects ; Water - pharmacology ; Zirconium - pharmacology ; Zirconium derivatives
É parte de: Journal of molecular evolution, 2010-08, Vol.71 (2), p.100-110
Notas: http://dx.doi.org/10.1007/s00239-010-9366-7
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Descrição: We describe the one-pot synthesis of a large variety of nucleic acid bases and related compounds from formamide in the presence of zirconium minerals as catalysts. The major products observed are: purine, 2-hydroxy pyrimidine, 5-hydroxy pyrimidine, isocytosine, adenine, urea, and carbodiimide. The synthesis of low molecular weight amides and carboxylic acid derivatives (intermediates of extant metabolism) was also observed: glyoxylamide, glycolic-, lactic-, succinic-, oxalic-, fumaric-, and maleic acids. As the major problem in the origin of informational polymers is the instability of their precursors, we also investigated the effects of zirconia minerals on the stability of ribooligonucleotides in formamide and in water. The relevance of these findings with respect to the origin of informational polymers and primordial metabolism is discussed.
Editor: New York: New York : Springer-Verlag
Idioma: Inglês

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Role of the Formamide/Zirconia System in the Synthesis of Nucleobases and Biogenic Carboxylic Acid Derivatives

Saladino, Raffaele ; Neri, Veronica ; Crestini, Claudia ; Costanzo, Giovanna ; Graciotti, Michele ; Di Mauro, Ernesto

New York: New York : Springer-Verlag

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