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Vascular events in viral hemorrhagic fevers: a comparative study of dengue and hantaviruses

Srikiatkhachorn, Anon ; Spiropoulou, Christina F

Cell and tissue research, 2014-03, Vol.355 (3), p.621-633 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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Título:
Vascular events in viral hemorrhagic fevers: a comparative study of dengue and hantaviruses
Autor: Srikiatkhachorn, Anon ; Spiropoulou, Christina F
Assuntos: Analysis ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Dengue ; Dengue fever ; Dengue Virus - isolation & purification ; endothelial cells ; Endothelial Cells - pathology ; Endothelium ; Endothelium, Vascular - pathology ; Hantavirus - isolation & purification ; Health aspects ; Hemorrhage ; Hemorrhagic Fevers, Viral - pathology ; Hemorrhagic Fevers, Viral - virology ; Human Genetics ; Humans ; immune response ; Infection ; Molecular Medicine ; morbidity ; mortality ; pathogenesis ; pathogens ; Permeability ; Plasma ; Proteomics ; Review ; thrombocytopenia ; Viral infections ; viruses
É parte de: Cell and tissue research, 2014-03, Vol.355 (3), p.621-633
Notas: http://dx.doi.org/10.1007/s00441-014-1841-9
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Descrição: Viral hemorrhagic diseases are a group of systemic viral infections with worldwide distribution and are significant causes of global mortality and morbidity. The hallmarks of viral hemorrhagic fevers are plasma leakage, thrombocytopenia, coagulopathy and hemorrhagic manifestations. The molecular mechanisms leading to plasma leakage in viral hemorrhagic fevers are not well understood. A common theme has emerged in which a complex interplay between pathogens, host immune response, and endothelial cells leads to the activation of endothelial cells and perturbation of barrier integrity. In this article, two clinically distinct viral hemorrhagic fevers caused by dengue viruses and hantaviruses are discussed to highlight their similarities and differences that may provide insights into the pathogenesis and therapeutic approach.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

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Vascular events in viral hemorrhagic fevers: a comparative study of dengue and hantaviruses

Srikiatkhachorn, Anon ; Spiropoulou, Christina F

Berlin/Heidelberg: Springer-Verlag

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