skip to main content
Idioma:

Clinical significance of hepatitis B surface antigen mutants

Coppola, Nicola ; Onorato, Lorenzo ; Minichini, Carmine ; Di Caprio, Giovanni ; Starace, Mario ; Sagnelli, Caterina ; Sagnelli, Evangelista

World journal of hepatology, 2015-11, Vol.7 (27), p.2729-2739

United States: Baishideng Publishing Group Inc

Texto completo disponível

Citações Citado por
  • Título:
    Clinical significance of hepatitis B surface antigen mutants
  • Autor: Coppola, Nicola ; Onorato, Lorenzo ; Minichini, Carmine ; Di Caprio, Giovanni ; Starace, Mario ; Sagnelli, Caterina ; Sagnelli, Evangelista
  • Assuntos: escape; Immune ; Hepatitis ; infection; Vaccine ; Review ; virus
  • É parte de: World journal of hepatology, 2015-11, Vol.7 (27), p.2729-2739
  • Notas: Hepatitis B virus infection;Vaccine escape;Immune
    Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBs Ag, called the "a" determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBs Ag detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBs Ag mutants and their biological and clinical implications.
    Nicola Coppola;Lorenzo Onorato;Carmine Minichini;Giovanni Di Caprio;Mario Starace;Caterina Sagnelli;Evangelista Sagnelli;Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples;Department of Clinical and Experimental Medicine and Surgery "F.Magrassi e A.Lanzara",Second University of Naples
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    ObjectType-Review-1
    Telephone: +39-8-15666719 Fax: +39-8-15666013
    Author contributions: Coppola N has contributed to conception of the paper and draft the article; Onorato L has analyzed the role of HBsAg mutants associated with HCC development; Minichini C has analyzed the HBV virology and HBsAg structure; Di Caprio G has analyzed the role of HBsAg mutants associated with immune escape; Starace M has analyzed the HBV virology and HBsAg structure; Sagnelli C has analyzed the role of HBsAg mutants associated with failed HBsAg detection; Sagnelli E has contributed to conception of the paper and draft the article.
    Correspondence to: Nicola Coppola, MD, PhD, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Via: L. Armanni 5, 80131 Naples, Italy. nicola.coppola@unina2.it
  • Descrição: Hepatitis B virus(HBV) infection is a major public health problem in many countries, with nearly 300 million people worldwide carrying HBV chronic infection and over 1 million deaths per year due to cirrhosis and liver cancer. Several hepatitis B surface antigen(HBs Ag) mutations have been described, most frequently due to a single amino acid substitution and seldom to a nucleotide deletion. The majority of mutations are located in the S region, but they have also been found in the pre-S1 and pre-S2 regions. Single amino acid substitutions in the major hydrophilic region of HBs Ag, called the "a" determinant, have been associated with immune escape and the consequent failure of HBV vaccination and HBs Ag detection, whereas deletions in the pre-S1 or pre-S2 regions have been associated with the development of hepatocellular carcinoma. This review article will focus on the HBs Ag mutants and their biological and clinical implications.
  • Editor: United States: Baishideng Publishing Group Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.