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Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex

Yokota, Yukako ; Gashghaei, H T ; Han, Christine ; Watson, Hannah ; Campbell, Kenneth J ; Anton, E S Chan-Ling, Tailoi

PloS one, 2007-08, Vol.2 (8), p.e794-e794 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex
Autor: Yokota, Yukako ; Gashghaei, H T ; Han, Christine ; Watson, Hannah ; Campbell, Kenneth J ; Anton, E S
Chan-Ling, Tailoi
Assuntos: Animals ; Brain ; Cell Biology/Cell Adhesion ; Cell Biology/Cell Signaling ; Cell Biology/Developmental Molecular Mechanisms ; Cell Biology/Morphogenesis and Cell Biology ; Cell Biology/Neuronal and Glial Cell Biology ; Cell Differentiation ; Cell migration ; Cell Movement - physiology ; Cell Polarity ; Cells, Cultured ; Cerebral cortex ; Cerebral Cortex - cytology ; Cerebral Cortex - embryology ; Cerebral Cortex - physiology ; Developmental Biology/Cell Differentiation ; Developmental Biology/Morphogenesis and Cell Biology ; Developmental Biology/Neurodevelopment ; Developmental Biology/Organogenesis ; Developmental Biology/Pattern Formation ; Developmental Biology/Stem Cells ; Embryo, Mammalian - metabolism ; Immunohistochemistry ; Interneurons ; Interneurons - cytology ; Interneurons - metabolism ; Leukocyte migration ; Medicine ; Mental disorders ; Mice ; Mice, Transgenic ; Neural networks ; Neurodevelopmental disorders ; Neuroglia - cytology ; Neuroglia - metabolism ; Neuroimaging ; Neurological Disorders/Developmental and Pediatric Neurology ; Neurons ; Neuroscience/Neurodevelopment ; Neuroscience/Neuronal and Glial Cell Biology ; Neurosciences ; Physiology ; Physiology/Neurodevelopment ; Population genetics ; Radial glial cells ; Schizophrenia ; Transcription factors
É parte de: PloS one, 2007-08, Vol.2 (8), p.e794-e794
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Current address: Department of Molecular Biomedical Sciences, School of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America
Conceived and designed the experiments: EA YY. Performed the experiments: EA YY TG CH. Analyzed the data: EA YY TG CH. Contributed reagents/materials/analysis tools: KC. Wrote the paper: EA YY HG CH KC. Other: Conducted most of the experiments: YY. Wrote the manuscript: YY. Collaboratively worked with the first author on the in vivo two-photon imaging of interneuronal migration in living embryos: HG. Contributed to the immunohistochemical analysis of distinct interneuronal subsets in the embryonic cortex: CH. Helped to analyze migration patterns of distinct interneuronal subsets in the embryonic cortex: HW. Generated the Dlx5/6-cre-IRES-EGFP mice used in the study: KC. Contributed to the writing of the manuscript: KC. Principal Investigator of the laboratory: EA. Contributed to data analysis: EA. Contributed to writing of the manuscript: EA.
Descrição: Interneurons originating from the ganglionic eminence migrate tangentially into the developing cerebral wall as they navigate to their distinct positions in the cerebral cortex. Compromised connectivity and differentiation of interneurons are thought to be an underlying cause in the emergence of neurodevelopmental disorders such as schizophrenia. Previously, it was suggested that tangential migration of interneurons occurs in a radial glia independent manner. Here, using simultaneous imaging of genetically defined populations of interneurons and radial glia, we demonstrate that dynamic interactions with radial glia can potentially influence the trajectory of interneuronal migration and thus the positioning of interneurons in cerebral cortex. Furthermore, there is extensive local interneuronal migration in tangential direction opposite to that of pallial orientation (i.e., in a medial to lateral direction from cortex to ganglionic eminence) all across the cerebral wall. This counter migration of interneurons may be essential to locally position interneurons once they invade the developing cerebral wall from the ganglionic eminence. Together, these observations suggest that interactions with radial glial scaffold and localized migration within the expanding cerebral wall may play essential roles in the guidance and placement of interneurons in the developing cerebral cortex.
Editor: United States: Public Library of Science
Idioma: Inglês

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Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex

Yokota, Yukako ; Gashghaei, H T ; Han, Christine ; Watson, Hannah ; Campbell, Kenneth J ; Anton, E S Chan-Ling, Tailoi

United States: Public Library of Science

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