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Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery

Gallay, Marc N. ; Jeanmonod, Daniel ; Liu, Jian ; Morel, Anne

Brain Structure and Function, 2008-08, Vol.212 (6), p.443-463 [Periódico revisado por pares]

Berlin/Heidelberg: Springer-Verlag

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Título:
Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery
Autor: Gallay, Marc N. ; Jeanmonod, Daniel ; Liu, Jian ; Morel, Anne
Assuntos: Acetylcholinesterase - metabolism ; Aged ; Anatomy & physiology ; Biomedical and Life Sciences ; Biomedicine ; Brain Mapping ; Brain research ; Calcium-Binding Proteins - metabolism ; Cell Biology ; Cerebellum - anatomy & histology ; Cerebellum - metabolism ; Female ; Globus Pallidus - anatomy & histology ; Globus Pallidus - metabolism ; Humans ; Magnetic Resonance Imaging - methods ; Middle Aged ; Models, Biological ; Neural Pathways - anatomy & histology ; Neural Pathways - metabolism ; Neurological disorders ; Neurology ; Neurosciences ; Neurosurgery ; Neurosurgical Procedures - methods ; Original ; Original Article ; Parvalbumins - metabolism ; Postmortem Changes ; Stereotaxic Techniques ; Thalamus - anatomy & histology ; Thalamus - metabolism
É parte de: Brain Structure and Function, 2008-08, Vol.212 (6), p.443-463
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Descrição: Anatomical knowledge of the structures to be targeted and of the circuitry involved is crucial in stereotactic functional neurosurgery. The present study was undertaken in the context of surgical treatment of motor disorders such as essential tremor (ET) and Parkinson’s disease (PD) to precisely determine the course and three-dimensional stereotactic localisation of the cerebellothalamic and pallidothalamic tracts in the human brain. The course of the fibre tracts to the thalamus was traced in the subthalamic region using multiple staining procedures and their entrance into the thalamus determined according to our atlas of the human thalamus and basal ganglia [Morel ( 2007 ) Stereotactic atlas of the human thalamus and basal ganglia. Informa Healthcare Inc., New York]. Stereotactic three-dimensional coordinates were determined by sectioning thalamic and basal ganglia blocks parallel to stereotactic planes and, in two cases, by correlation with magnetic resonance images (MRI) from the same brains prior to sectioning. The major contributions of this study are to provide: (1) evidence that the bulks of the cerebellothalamic and pallidothalamic tracts are clearly separated up to their thalamic entrance, (2) stereotactic maps of the two tracts in the subthalamic region, (3) the possibility to discriminate between different subthalamic fibre tracts on the basis of immunohistochemical stainings, (4) correlations of histologically identified fibre tracts with high-resolution MRI, and (5) evaluation of the interindividual variability of the fibre systems in the subthalamic region. This study should provide an important basis for accurate stereotactic neurosurgical targeting of the subthalamic region in motor disorders such as PD and ET.
Editor: Berlin/Heidelberg: Springer-Verlag
Idioma: Inglês

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Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery

Gallay, Marc N. ; Jeanmonod, Daniel ; Liu, Jian ; Morel, Anne

Berlin/Heidelberg: Springer-Verlag

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