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Epigenomics may begin to explain in vitro differential response to hypomethylating agents in MMR-D hypermethylated endometrial cancer

El Khoury, Louis Y ; Lin, Wan Hsin ; Smadbeck, James B ; Barrett, Michael T ; Sadeghian, Dorsay ; McCune, Alexa F ; Karagouga, Giannoula ; Cheville, John C ; Harris, Faye R ; Kinsella, Lindsey M ; Feathers, Ryan W ; Schafer Klein, Janet L ; Walther-Antonio, Marina Rs ; Johnson, Sarah H ; Penheiter, Alan R ; Cucinella, Giuseppe ; Schivardi, Gabriella ; Bhagwate, Aditya ; Borad, Mitesh J ; Mansfield, Aaron S ; Murphy, Stephen J ; Mariani, Andrea ; Vasmatzis, George ; Anastasiadis, Panos Z ; Weroha, Saravut J ; Larish, Alyssa M

Epigenomics, 2023-03, Vol.15 (5), p.283-292 [Periódico revisado por pares]

England

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Título:
Epigenomics may begin to explain in vitro differential response to hypomethylating agents in MMR-D hypermethylated endometrial cancer
Autor: El Khoury, Louis Y ; Lin, Wan Hsin ; Smadbeck, James B ; Barrett, Michael T ; Sadeghian, Dorsay ; McCune, Alexa F ; Karagouga, Giannoula ; Cheville, John C ; Harris, Faye R ; Kinsella, Lindsey M ; Feathers, Ryan W ; Schafer Klein, Janet L ; Walther-Antonio, Marina Rs ; Johnson, Sarah H ; Penheiter, Alan R ; Cucinella, Giuseppe ; Schivardi, Gabriella ; Bhagwate, Aditya ; Borad, Mitesh J ; Mansfield, Aaron S ; Murphy, Stephen J ; Mariani, Andrea ; Vasmatzis, George ; Anastasiadis, Panos Z ; Weroha, Saravut J ; Larish, Alyssa M
É parte de: Epigenomics, 2023-03, Vol.15 (5), p.283-292
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: This work examines differences in chromatin accessibility, methylation, and response to DNA hypomethylating agents between mismatch repair-deficient and non-mismatch repair-deficient endometrial cancer. Next-generation sequencing of a stage 1B, grade 2 endometrioid endometrial cancer tumor revealed microsatellite instability and a variant of unknown significance in along with global and hypermethylation. Inhibition of viability by decitabine in the study and comparison tumors was minimal, as shown by an inhibitory effect of 0 and 17.9, respectively. Conversely, the inhibitory effect of azacitidine on the study tumor was more pronounced, at 72.8 versus 41.2. , mismatch repair-deficient endometrial cancer with hypermethylation respond better to DNA methyltransferase inhibition by azacytidine (DNA/RNA inhibition), than to decitabine (DNA-only inhibition). Additional large studies are needed to substantiate our findings.
Editor: England
Idioma: Inglês

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Epigenomics may begin to explain in vitro differential response to hypomethylating agents in MMR-D hypermethylated endometrial cancer

England

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