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Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen

Rizzieri, David A. ; Long, Gwynn D. ; Vredenburgh, James J. ; Gasparetto, Christina ; Morris, Ashley ; Stenzel, Timothy T. ; Davis, Patti ; Chao, Nelson J.

Blood, 2001-12, Vol.98 (12), p.3486-3488 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen
Autor: Rizzieri, David A. ; Long, Gwynn D. ; Vredenburgh, James J. ; Gasparetto, Christina ; Morris, Ashley ; Stenzel, Timothy T. ; Davis, Patti ; Chao, Nelson J.
Assuntos: Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Fetal Blood - cytology ; Graft Survival ; Hematopoietic Stem Cell Transplantation ; Histocompatibility ; Humans ; Lymphoma, Large B-Cell, Diffuse - therapy ; Lymphoma, Mantle-Cell - therapy ; Male ; Medical sciences ; Middle Aged ; Remission Induction ; Tissue Donors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation Conditioning ; Transplantation, Homologous
É parte de: Blood, 2001-12, Vol.98 (12), p.3486-3488
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Reduction in the toxicity of allogeneic transplantation with nonmyeloablative induction regimens has expanded the scope of practice to older and more debilitated patients. However, the limited availability of matched sibling donors requires that alternative donor sources be investigated. Reported here are 2 cases of patients with advanced hematologic malignancies without matched siblings, partially matched family members, or matched unrelated donors who successfully underwent nonmyeloablative conditioning therapy followed by infusion of partially matched, unrelated-donor cord blood cells. The patients are in remission and remain 100% donor as assessed by short tandem repeat analysis of the marrow 6 and 12 months following transplantation.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen

Rizzieri, David A. ; Long, Gwynn D. ; Vredenburgh, James J. ; Gasparetto, Christina ; Morris, Ashley ; Stenzel, Timothy T. ; Davis, Patti ; Chao, Nelson J.

Washington, DC: Elsevier Inc

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