Idioma:

Yeast clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis

Jonassen, T ; Proft, M ; Randez-Gil, F ; Schultz, J.R ; Marbois, B.N ; Entian, K.D ; Clarke, C.F

The Journal of biological chemistry, 1998-02, Vol.273 (6), p.3351-3357 [Periódico revisado por pares]

United States: American Society for Biochemistry and Molecular Biology

Texto completo disponível

Citações Citado por

Enviar para

Título:
Yeast clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis
Autor: Jonassen, T ; Proft, M ; Randez-Gil, F ; Schultz, J.R ; Marbois, B.N ; Entian, K.D ; Clarke, C.F
Assuntos: ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; ADN RECOMBINADO ; ADN RECOMBINE ; Amino Acid Sequence ; BETA GALACTOSIDASA ; BETA GALACTOSIDASE ; BIOSINTESIS ; BIOSYNTHESE ; BIOSYNTHESIS ; Caenorhabditis elegans Proteins ; CELL MEMBRANES ; ENZYMIC ACTIVITY ; ETANOL ; ETHANOL ; EXPRESION GENICA ; EXPRESSION DES GENES ; FENOTIPOS ; Fungal Proteins - metabolism ; GENE ; GENE EXPRESSION ; GENES ; GENETIC REGULATION ; GENETICA ; GENETICS ; GENETIQUE ; Gluconeogenesis ; GLUCOSA ; GLUCOSE ; Glucose - metabolism ; Helminth Proteins - metabolism ; Intracellular Membranes - metabolism ; ISOCITRATE LYASE ; ISOCITRATO LIASA ; LIASAS ; LYASE ; LYASES ; MEMBRANAS CELULARES ; MEMBRANE CELLULAIRE ; MITOCHONDRIA ; Mitochondria - metabolism ; MITOCHONDRIAL INNER MEMBRANES ; MITOCHONDRIE ; MITOCONDRIA ; Molecular Sequence Data ; MUTACION ; MUTANT ; MUTANTES ; MUTANTS ; MUTATION ; PHENOTYPE ; PHENOTYPES ; PHOSPHOENOLPYRUVATE CARBOXYKINASE ; PROMOTERS ; PROTEINAS ; PROTEINE ; PROTEINS ; QUINONAS ; QUINONE ; QUINONES ; RECOMBINANT DNA ; REPORTER GENES ; RESPIRACION ; RESPIRATION ; SACCHAROMYCES CEREVISIAE ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins ; Sequence Homology, Amino Acid ; Ubiquinone - biosynthesis ; Ubiquinone - genetics ; Ubiquinone - metabolism ; UBIQUINONES
É parte de: The Journal of biological chemistry, 1998-02, Vol.273 (6), p.3351-3357
Notas: F60
1997067785
F30
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: Mutations in the clk-1 gene result in slower development and increased life span in Caenorhabditis elegans . The Saccharomyces cerevisiae homologue COQ7/CAT5 is essential for several metabolic pathways including ubiquinone biosynthesis, respiration, and gluconeogenic gene activation. We show here that Coq7p/Cat5p is a mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, and that the defect in gluconeogenic gene activation in coq7/cat5 null mutants is a general consequence of a defect in respiration. These results obtained in the yeast model suggest that the effects on development and life span in C. elegans clk-1 mutants may relate to changes in the amount of ubiquinone, an essential electron transport component and a lipid soluble antioxidant.
Editor: United States: American Society for Biochemistry and Molecular Biology
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Yeast clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis

Jonassen, T ; Proft, M ; Randez-Gil, F ; Schultz, J.R ; Marbois, B.N ; Entian, K.D ; Clarke, C.F

United States: American Society for Biochemistry and Molecular Biology

Buscando em bases de dados remotas. Favor aguardar.