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The Rocky Road to a Digital Lab

Sagmeister, Peter ; Williams, Jason D. ; Kappe, C. Oliver

Chimia, 2023-05, Vol.77 (5), p.300-306 [Periódico revisado por pares]

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Título:
The Rocky Road to a Digital Lab
Autor: Sagmeister, Peter ; Williams, Jason D. ; Kappe, C. Oliver
Assuntos: Automated platform ; Digitalization ; Flow chemistry ; PAT
É parte de: Chimia, 2023-05, Vol.77 (5), p.300-306
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The pharmaceutical industry has begun incorporating continuous manufacturing technology in synthetic routes toward active pharmaceutical ingredients (APIs). The development of smart manufacturing routes can be accelerated by utilizing digitalization, process analytical technology (PAT), and data-rich experimentation from an early stage. Here, we present the key aspects of implementing automated flow chemistry reactor platforms with real-time process analytics. Based on our experiences in this field, we aim to highlight the potential of these platforms to conduct self-optimization, automated reaction model building, dynamic experiments and to implement advanced process control strategies
Editor: Swiss Chemical Society
Idioma: Inglês;Alemão

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