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Molecular Modeling, Synthesis, and Preliminary Biological Evaluation of Glutathione-S-Transferase Inhibitors as Potential Therapeutic Agents

Procopio, Antonio ; Alcaro, Stefano ; Cundari, Sante ; De Nino, Antonio ; Ortuso, Francesco ; Sacchetta, Paolo ; Pennelli, Alfonso ; Sindona, Giovanni

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6084-6089 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
Molecular Modeling, Synthesis, and Preliminary Biological Evaluation of Glutathione-S-Transferase Inhibitors as Potential Therapeutic Agents
Autor: Procopio, Antonio ; Alcaro, Stefano ; Cundari, Sante ; De Nino, Antonio ; Ortuso, Francesco ; Sacchetta, Paolo ; Pennelli, Alfonso ; Sindona, Giovanni
Assuntos: Antineoplastic agents ; Biological and medical sciences ; Catalytic Domain ; Ethylene Oxide - analogs & derivatives ; Ethylene Oxide - chemical synthesis ; Ethylene Oxide - chemistry ; General aspects ; Glutathione - analogs & derivatives ; Glutathione - chemical synthesis ; Glutathione - chemistry ; Glutathione Transferase - antagonists & inhibitors ; Glutathione Transferase - chemistry ; Humans ; Medical sciences ; Miscellaneous ; Models, Molecular ; Pharmacology. Drug treatments ; Quantitative Structure-Activity Relationship
É parte de: Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6084-6089
Notas: Università della Calabria.
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Descrição: Changes in the GSH/GST system have been found to correlate with resistance to anticancer alkylating agents, presumably through accelerated detoxification of these drugs since some GSTs have been shown to catalyze the conjugation of GSH to specific antineoplastic agents. GSH-alkyl derivatives were designed by molecular modeling, synthesized, and tested as inhibitors of human GST-Pi.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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Molecular Modeling, Synthesis, and Preliminary Biological Evaluation of Glutathione-S-Transferase Inhibitors as Potential Therapeutic Agents

Procopio, Antonio ; Alcaro, Stefano ; Cundari, Sante ; De Nino, Antonio ; Ortuso, Francesco ; Sacchetta, Paolo ; Pennelli, Alfonso ; Sindona, Giovanni

Washington, DC: American Chemical Society

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