Idioma:

Pre-eclampsia and expression of heparin-binding EGF-like growth factor

Leach, Richard E ; Romero, Roberto ; Kim, Yeon Mee ; Chaiworapongsa, Tinnakorn ; Kilburn, Brian ; Das, Sanjoy K ; Dey, Sudhansu K ; Johnson, Anthony ; Qureshi, Faisal ; Jacques, Suzanne ; Armant, D Randall

The Lancet (British edition), 2002-10, Vol.360 (9341), p.1215-1219 [Periódico revisado por pares]

London: Elsevier Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Pre-eclampsia and expression of heparin-binding EGF-like growth factor
Autor: Leach, Richard E ; Romero, Roberto ; Kim, Yeon Mee ; Chaiworapongsa, Tinnakorn ; Kilburn, Brian ; Das, Sanjoy K ; Dey, Sudhansu K ; Johnson, Anthony ; Qureshi, Faisal ; Jacques, Suzanne ; Armant, D Randall
Assuntos: Adult ; Analysis of Variance ; Biological and medical sciences ; Cellular biology ; Diseases of mother, fetus and pregnancy ; Epidermal Growth Factor - analysis ; Epidermal Growth Factor - genetics ; Female ; Gynecology. Andrology. Obstetrics ; Heparin-binding EGF-like Growth Factor ; Humans ; Image Processing, Computer-Assisted ; Immunohistochemistry - methods ; In Situ Hybridization - methods ; Infant, Newborn ; Infant, Premature ; Intercellular Signaling Peptides and Proteins ; Medical disorders ; Medical sciences ; Physical growth ; Placenta - chemistry ; Placenta - pathology ; Pre-Eclampsia - metabolism ; Pre-Eclampsia - pathology ; Pregnancy ; Pregnancy Trimester, Third ; Pregnancy. Fetus. Placenta ; Proteins ; Receptors, Growth Factor ; RNA, Messenger - analysis ; Statistics, Nonparametric ; Trophoblasts - chemistry ; Trophoblasts - pathology
É parte de: The Lancet (British edition), 2002-10, Vol.360 (9341), p.1215-1219
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Pre-eclampsia is a disorder of pregnancy associated with poor extravillous cytotrophoblast invasion and above-normal rates of apoptosis in the trophoblast. Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) has strong cytoprotective activity and is an important signalling protein that regulates trophoblast invasion during early placentation. We aimed to establish whether HB-EGF expression is altered in placentae of pre-eclamptic women. We assessed the expression of HB-EGF mRNA and protein by in-situ hybridisation and immunohistochemical techniques, respectively, in archived placental tissues from pregnancies terminated at around 20 weeks of gestation, and from women delivering between weeks 19 and 35 of gestation with preterm labour, small for gestational age infants, or pre-eclampsia. HB-EGF mRNA and protein were expressed in villous and extravillous cytotrophoblast cells up to week 35 of gestation in placentae from women who delivered preterm. Similar levels of HB-EGF protein were found in the placentae of women who were not in labour. HB-EGF expression was reduced about five-fold (p=0·0001) in pre-eclamptic pregnancies. Fetal growth retardation, which has been linked with shallow trophoblast invasion and moderate apoptosis, was associated with placentae expressing intermediate levels of HB-EGF. In pre-eclampsia, deficient HB-EGF signalling during placental development could impair trophoblast survival, differentiation, and invasion, leading to poor placental perfusion and hypertension.
Editor: London: Elsevier Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Pre-eclampsia and expression of heparin-binding EGF-like growth factor

Leach, Richard E ; Romero, Roberto ; Kim, Yeon Mee ; Chaiworapongsa, Tinnakorn ; Kilburn, Brian ; Das, Sanjoy K ; Dey, Sudhansu K ; Johnson, Anthony ; Qureshi, Faisal ; Jacques, Suzanne ; Armant, D Randall

London: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.