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Association between liver insulin resistance and cardiovascular risk factors

Vangipurapu, J. ; Stančáková, A. ; Kuulasmaa, T. ; Soininen, P. ; Kangas, A. J. ; Ala-Korpela, M. ; Kuusisto, J. ; Laakso, M.

Journal of internal medicine, 2012-10, Vol.272 (4), p.402-408 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Association between liver insulin resistance and cardiovascular risk factors
Autor: Vangipurapu, J. ; Stančáková, A. ; Kuulasmaa, T. ; Soininen, P. ; Kangas, A. J. ; Ala-Korpela, M. ; Kuusisto, J. ; Laakso, M.
Assuntos: Age ; Biological and medical sciences ; Body mass ; cardiovascular disease risk ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cholesterol ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; General aspects ; Hospitals ; Humans ; Insulin ; Insulin Resistance ; lipoproteins ; Liver ; Liver - metabolism ; Male ; Medical sciences ; Middle Aged ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; Sensitivity ; type 2 diabetes
É parte de: Journal of internal medicine, 2012-10, Vol.272 (4), p.402-408
Notas: istex:85300ABA4CAB51E2D67F8006FA23ED4444E6B100
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Descrição: . Vangipurapu J, Stančáková A, Kuulasmaa T, Soininen P, Kangas AJ, Ala‐Korpela M, Kuusisto J, Laakso M (University of Eastern Finland and Kuopio University Hospital, Kuopio; University of Oulu and Biocenter Oulu, Oulu, Finland). Association between liver insulin resistance and cardiovascular risk factors. J Intern Med 2012; 272: 402–408. Objectives. The objective of this study was to examine the associations between indices of liver insulin resistance (IR) and whole‐body insulin sensitivity and different cardiovascular disease (CVD) risk factors. Design and subjects. A total of 8750 nondiabetic men (age 57.2 ± 7.1 years, body mass index 26.8 ± 3.8 kg m−2) were included in this study from the population‐based cross‐sectional Metabolic Syndrome In Men (METSIM) cohort. Liver IR index and Matsuda insulin sensitivity index (ISI) were used as markers of liver IR and whole‐body insulin sensitivity, respectively. Pearson correlation analysis was performed to examine the associations between these indices and various CVD risk factors. Results. Total cholesterol (r = −0.088 vs. r = 0.020; P < 0.0019), high‐sensitivity C‐reactive protein (CRP) (r = 0.284 vs. r = −0.219; P < 0.0019) and total triglycerides (r = 0.507 vs. r = −0.477; P < 0.05) were more highly correlated with liver IR index than with Matsuda ISI. By contrast, Matsuda ISI was nominally more highly correlated with systolic and diastolic blood pressure (r = −0.234 and r = −0.275 vs. r = 0.202 and r = 0.239, respectively) compared to liver IR index. Furthermore, the variance explained by liver IR index was larger than that explained by Matsuda ISI for the majority of CVD risk factors measured. Conclusions. Liver IR index correlated more strongly than Matsuda ISI with levels of total cholesterol, CRP and triglycerides. Therefore, liver IR might be a significant indicator of CVD risk amongst men.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Association between liver insulin resistance and cardiovascular risk factors

Vangipurapu, J. ; Stančáková, A. ; Kuulasmaa, T. ; Soininen, P. ; Kangas, A. J. ; Ala-Korpela, M. ; Kuusisto, J. ; Laakso, M.

Oxford, UK: Blackwell Publishing Ltd

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