skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study

Fjelltveit, Elisabeth B ; Blomberg, Bjørn ; Kuwelker, Kanika ; Zhou, Fan ; Onyango, Therese B ; Brokstad, Karl A ; Elyanow, Rebecca ; Kaplan, Ian M ; Tøndel, Camilla ; Mohn, Kristin G I ; Özgümüş, Türküler ; Cox, Rebecca J ; Langeland, Nina

Clinical infectious diseases, 2023-02, Vol.76 (3), p.e60-e70 [Periódico revisado por pares]

United States

Texto completo disponível

Citações Citado por
  • Título:
    Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study
  • Autor: Fjelltveit, Elisabeth B ; Blomberg, Bjørn ; Kuwelker, Kanika ; Zhou, Fan ; Onyango, Therese B ; Brokstad, Karl A ; Elyanow, Rebecca ; Kaplan, Ian M ; Tøndel, Camilla ; Mohn, Kristin G I ; Özgümüş, Türküler ; Cox, Rebecca J ; Langeland, Nina
  • Assuntos: Adult ; Case-Control Studies ; COVID-19 ; Dyspnea ; Female ; Humans ; Memory Disorders ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2
  • É parte de: Clinical infectious diseases, 2023-02, Vol.76 (3), p.e60-e70
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The burden and duration of persistent symptoms after nonsevere coronavirus disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection symptom trajectories in home-isolated COVID-19 cases compared with age- and time- matched seronegative controls, and investigate immunological correlates of long COVID. A prospective case-control study included home-isolated COVID-19 cases between February 28 and April 4, 2020, and followed for 12 (n = 233) to 18 (n = 149) months, and 189 age-matched severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive controls. We collected clinical data at baseline, 6, 12, and 18 months postinfection, and blood samples at 2, 4, 6, and 12 months for analysis of SARS-CoV-2-specific humoral and cellular responses. Overall, 46% (108/233) had persisting symptoms 12 months after COVID-19. Compared with controls, adult cases had a high risk of fatigue (27% excess risk, sex, and comorbidity adjusted odds ratio [aOR] 5.86; 95% confidence interval [CI], 3.27-10.5), memory problems (21% excess risk; aOR 7.42; CI, 3.51-15.67), concentration problems (20% excess risk; aOR 8.88; 95% CI, 3.88-20.35), and dyspnea (10% excess risk; aOR 2.66; 95% CI, 1.22-5.79). The prevalence of memory problems increased overall from 6 to 18 months (excess risk 11.5%; 95% CI, 1.5-21.5; P = .024) and among women (excess risk 18.7%; 95% CI, 4.4-32.9; P = .010). Longitudinal spike immunoglobulin G was significantly associated with dyspnea at 12 months. The spike-specific clonal CD4+ T-cell receptor β depth was significantly associated with both dyspnea and number of symptoms at 12 months. This study documents a high burden of persisting symptoms after mild COVID-19 and suggests that infection induced SARS-CoV-2-specific immune responses may influence long-term symptoms.
  • Editor: United States
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.