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Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus

de Carvalho, Gabriel Costa ; Domingues, Rosana ; de Sousa Nogueira, Marcelle Almeida ; Calvielli Castelo Branco, Anna C ; Gomes Manfrere, Kelly C ; Pereira, Naiura Vieira ; Aoki, Valéria ; Sotto, Mirian Nacagami ; Da Silva Duarte, Alberto J ; Sato, Maria Notomi

Acta dermato-venereologica, 2016-01, Vol.96 (4), p.485-489 [Periódico revisado por pares]

Sweden

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Título:
Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus
Autor: de Carvalho, Gabriel Costa ; Domingues, Rosana ; de Sousa Nogueira, Marcelle Almeida ; Calvielli Castelo Branco, Anna C ; Gomes Manfrere, Kelly C ; Pereira, Naiura Vieira ; Aoki, Valéria ; Sotto, Mirian Nacagami ; Da Silva Duarte, Alberto J ; Sato, Maria Notomi
Assuntos: Calgranulin A - immunology ; Calgranulin A - metabolism ; Calgranulin B - immunology ; Calgranulin B - metabolism ; Case-Control Studies ; CD56 Antigen - immunology ; CD56 Antigen - metabolism ; CD8-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - metabolism ; Cells, Cultured ; Cytokines - genetics ; Cytokines - immunology ; Cytokines - metabolism ; Humans ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Lichen Planus - genetics ; Lichen Planus - immunology ; Lichen Planus - metabolism ; Lichen Planus - pathology ; Lysosomal-Associated Membrane Protein 1 - immunology ; Lysosomal-Associated Membrane Protein 1 - metabolism ; Signal Transduction ; Skin - immunology ; Skin - metabolism ; Skin - pathology ; Toll-Like Receptor 4 - immunology ; Toll-Like Receptor 4 - metabolism ; Up-Regulation
É parte de: Acta dermato-venereologica, 2016-01, Vol.96 (4), p.485-489
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Increased expression of interleukin (IL)-1?, tumour necrosis factor (TNF) and IL-6 in the CD8+ T cells of patients with LP was induced by S100A8, in contrast to the control group that produced IL- 10 and interferon type I genes. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.
Editor: Sweden
Idioma: Inglês

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Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus

de Carvalho, Gabriel Costa ; Domingues, Rosana ; de Sousa Nogueira, Marcelle Almeida ; Calvielli Castelo Branco, Anna C ; Gomes Manfrere, Kelly C ; Pereira, Naiura Vieira ; Aoki, Valéria ; Sotto, Mirian Nacagami ; Da Silva Duarte, Alberto J ; Sato, Maria Notomi

Sweden

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