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Pathogenicity and virulence of Staphylococcus aureus

Cheung, Gordon Y. C. ; Bae, Justin S. ; Otto, Michael

Virulence, 2021-12, Vol.12 (1), p.547-569 [Periódico revisado por pares]

United States: Taylor & Francis

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Título:
Pathogenicity and virulence of Staphylococcus aureus
Autor: Cheung, Gordon Y. C. ; Bae, Justin S. ; Otto, Michael
Assuntos: Animals ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; biofilm ; Humans ; immune evasion ; infection ; Methicillin-Resistant Staphylococcus aureus - pathogenicity ; Mice ; mrsa ; neutrophils ; Quorum Sensing ; Review ; Sepsis ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - immunology ; Staphylococcal Infections - microbiology ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - genetics ; Staphylococcus aureus - pathogenicity ; toxins ; Virulence ; Virulence Factors - genetics
É parte de: Virulence, 2021-12, Vol.12 (1), p.547-569
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Staphylococcus aureus is one of the most frequent worldwide causes of morbidity and mortality due to an infectious agent. This pathogen can cause a wide variety of diseases, ranging from moderately severe skin infections to fatal pneumonia and sepsis. Treatment of S. aureus infections is complicated by antibiotic resistance and a working vaccine is not available. There has been ongoing and increasing interest in the extraordinarily high number of toxins and other virulence determinants that S. aureus produces and how they impact disease. In this review, we will give an overview of how S. aureus initiates and maintains infection and discuss the main determinants involved. A more in-depth understanding of the function and contribution of S. aureus virulence determinants to S. aureus infection will enable us to develop anti-virulence strategies to counteract the lack of an anti-S. aureus vaccine and the ever-increasing shortage of working antibiotics against this important pathogen.
Editor: United States: Taylor & Francis
Idioma: Inglês

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Pathogenicity and virulence of Staphylococcus aureus

Cheung, Gordon Y. C. ; Bae, Justin S. ; Otto, Michael

United States: Taylor & Francis

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