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Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM

GLAUBER, H ; WALLACE, P ; BRECHTEL, G

Diabetes (New York, N.Y.), 1987-10, Vol.36 (10), p.1187-1194 [Periódico revisado por pares]

Alexandria, VA: American Diabetes Association

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Título:
Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM
Autor: GLAUBER, H ; WALLACE, P ; BRECHTEL, G
Assuntos: 550201 - Biochemistry- Tracer Techniques ; 550901 - Pathology- Tracer Techniques ; ALDEHYDES ; BASIC BIOLOGICAL SCIENCES ; BIOCHEMICAL REACTION KINETICS ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; Blood Glucose - metabolism ; BODY ; CARBOHYDRATES ; DIABETES MELLITUS ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes. Impaired glucose tolerance ; DIGESTIVE SYSTEM ; DISEASES ; ENDOCRINE DISEASES ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; FASTING ; Female ; GLANDS ; GLUCAGON ; Glucagon - blood ; GLUCOSE ; Glucose - metabolism ; GLYCOGEN ; Glycogen - metabolism ; HEXOSES ; HORMONES ; Humans ; INSULIN ; Insulin - blood ; ISOTOPE APPLICATIONS ; KINETICS ; LABELLED COMPOUNDS ; LIVER ; Liver - metabolism ; Male ; Medical sciences ; METABOLIC DISEASES ; METABOLISM ; Middle Aged ; MONOSACCHARIDES ; ORGANIC COMPOUNDS ; ORGANS ; PATHOGENESIS ; PATIENTS ; PEPTIDE HORMONES ; PEPTIDES ; POLYPEPTIDES ; POLYSACCHARIDES ; PROTEINS ; REACTION KINETICS ; SACCHARIDES ; TRACER TECHNIQUES ; Tritium ; TRITIUM COMPOUNDS
É parte de: Diabetes (New York, N.Y.), 1987-10, Vol.36 (10), p.1187-1194
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: We studied the measurement of hepatic glucose output (HGO) with prolonged [3-3H]glucose infusion in 14 patients with non-insulin-dependent diabetes mellitus (NIDDM). Over the course of 10.5 h, plasma glucose concentration fell with fasting by one-third, from 234 +/- 21 to 152 +/- 12 mg/dl, and HGO fell from 2.35 +/- 0.18 to 1.36 +/- 0.07 mg . kg-1 . min-1 (P less than .001). In the basal state, HGO and glucose were significantly correlated (r = 0.68, P = .03), and in individual patients, HGO and glucose were closely correlated as both fell with fasting (mean r = 0.79, P less than .01). Plasma [3-3H]glucose radioactivity approached a steady state only 5-6 h after initiation of the primed continuous infusion, and a 20% overestimate of HGO was demonstrated by not allowing sufficient time for tracer labeling of the glucose pool. Assumption of steady-state instead of non-steady-state kinetics in using Steele's equations to calculate glucose turnover resulted in a 9-24% overestimate of HGO. Stimulation of glycogenolysis by glucagon injection demonstrated no incorporation of [3-3H]glucose in hepatic glycogen during the prolonged tracer infusion. In a separate study, plasma glucose was maintained at fasting levels (207 +/- 17 mg/dl) for 8 h with the glucose-clamp technique. Total glucose turnover rates remained constant during this prolonged tracer infusion. However, HGO fell to 30% of the basal value simply by maintaining fasting hyperglycemia in the presence of basal insulin levels.
Editor: Alexandria, VA: American Diabetes Association
Idioma: Inglês

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Effects of fasting on plasma glucose and prolonged tracer measurement of hepatic glucose output in NIDDM

GLAUBER, H ; WALLACE, P ; BRECHTEL, G

Alexandria, VA: American Diabetes Association

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