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Sensitivity Analysis of a Model of Human Papillomavirus Late Promoter Regulation

Giaretta, A ; Toffolo, G M

Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), 2019, Vol.2019, p.2913

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Título:
Sensitivity Analysis of a Model of Human Papillomavirus Late Promoter Regulation
Autor: Giaretta, A ; Toffolo, G M
Assuntos: Gene Expression Regulation, Viral ; Humans ; Models, Theoretical ; Papillomaviridae - genetics ; Papillomavirus Infections - virology ; Promoter Regions, Genetic ; RNA Splicing
É parte de: Conference proceedings (IEEE Engineering in Medicine and Biology Society. Conf.), 2019, Vol.2019, p.2913
Descrição: A mathematical model of Human Papillomavirus late promoter regulation was recently developed, able to predict the main features of HPV gene expression during cellular differentiation under productive infection. A sensitivity analysis is performed to characterize the influence of transcriptional, post-transcriptional and translational regulations on the viral species related to E1, E2, E4 and Li genes. Sensitivity analysis indicates strong influence of parameters related to transcriptional and translational regulation. It also shows a strong influence on the parameters related to post-transcriptional regulation, showing the importance of modeling splicing regulation to well describe the biology of the late promoter.
Editor: United States
Idioma: Inglês

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