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A 3-D framework for arterial growth and remodeling in response to altered hemodynamics

Karšaj, I. ; Sorić, J. ; Humphrey, J.D.

International journal of engineering science, 2010-11, Vol.48 (11), p.1357-1372 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
A 3-D framework for arterial growth and remodeling in response to altered hemodynamics
Autor: Karšaj, I. ; Sorić, J. ; Humphrey, J.D.
Assuntos: Adaptation ; Arterial hypertension. Arterial hypotension ; Arteries ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood pressure ; Blood vessels and receptors ; Cardiology. Vascular system ; Computer simulation ; Constituents ; Constrained mixture model ; Elastin ; Exact sciences and technology ; Finite elasticity ; Fundamental and applied biological sciences. Psychology ; Fundamental areas of phenomenology (including applications) ; Hemodynamics. Rheology ; Hypertension ; Mathematical models ; Medical sciences ; Nonlinearity ; Numerical prediction ; Physics ; Remodeling ; Solid mechanics ; Static elasticity (thermoelasticity...) ; Structural and continuum mechanics ; Vertebrates: cardiovascular system
É parte de: International journal of engineering science, 2010-11, Vol.48 (11), p.1357-1372
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Descrição: We present a three-dimensional mathematical framework for modeling the evolving geometry, structure, and mechanical properties of a representative straight cylindrical artery subjected to changes in mean blood pressure and flow. We show that numerical predictions recover prior findings from a validated two-dimensional framework, but extend those findings by allowing effects of transmural gradients in wall constituents and vasoactive molecules to be simulated directly. Of particular note, we show that the predicted evolution of the residual stress related opening angle in response to an abrupt, sustained increase in blood pressure is qualitatively similar to measured changes when one accounts for a nonlinear transmural distribution of pre-stretched elastin. We submit that continuum-based constrained mixture models of arterial adaptation hold significant promise for deepening our basic understanding of arterial mechanobiology and thus for designing improved clinical interventions to treat many different types of arterial disease and injury.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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A 3-D framework for arterial growth and remodeling in response to altered hemodynamics

Karšaj, I. ; Sorić, J. ; Humphrey, J.D.

Kidlington: Elsevier Ltd

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