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Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia

Sakabe, Koichi ; Fukuda, Nobuo ; Wakayama, Katsunori ; Nada, Teru ; Shinohara, Hisanori ; Tamura, Yoshiyuki

The American journal of cardiology, 2004-08, Vol.94 (4), p.497-500 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia
Autor: Sakabe, Koichi ; Fukuda, Nobuo ; Wakayama, Katsunori ; Nada, Teru ; Shinohara, Hisanori ; Tamura, Yoshiyuki
Assuntos: Adult ; Aged ; Anticholesteremic Agents - adverse effects ; Anticholesteremic Agents - therapeutic use ; Atorvastatin Calcium ; Basilar Artery - drug effects ; Biological and medical sciences ; Cardiology. Vascular system ; Cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical outcomes ; Disorders of blood lipids. Hyperlipoproteinemia ; Drug therapy ; Endothelium, Vascular - drug effects ; Female ; Fibrinolysis - drug effects ; Follow-Up Studies ; Heart ; Heptanoic Acids - adverse effects ; Heptanoic Acids - therapeutic use ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hypercholesterolemia - blood ; Hypercholesterolemia - drug therapy ; Long-Term Care ; Low density lipoprotein ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Plasminogen Activator Inhibitor 1 - blood ; Prospective Studies ; Pyrroles - adverse effects ; Pyrroles - therapeutic use ; Thiobarbituric Acid Reactive Substances - metabolism ; Treatment Outcome ; Triglycerides - blood ; Vasodilation - drug effects
É parte de: The American journal of cardiology, 2004-08, Vol.94 (4), p.497-500
Descrição: In this prospective study, we found beneficial short-term effects from atorvastatin therapy, including effects on low-density lipoprotein subfractions and remnant-like lipoprotein particle cholesterol, antioxidant effects, and alterations in endothelial function that may be important in early benefit from statin therapy; some effects would support much earlier benefit than previously reported. We also found long-term effects of atorvastatin, including decreased plasminogen activator inhibitor type-1 and additional significant alterations in low-density lipoprotein subfractions and endothelial function, supporting benefits from continuous long-term atorvastatin therapy beyond early reversal of hypercholesterolemia.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia

Sakabe, Koichi ; Fukuda, Nobuo ; Wakayama, Katsunori ; Nada, Teru ; Shinohara, Hisanori ; Tamura, Yoshiyuki

New York, NY: Elsevier Inc

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